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The new Covid variant JN.1 is causing a resurgence of pandemic havoc.

A feature of JN.1 is its potential to cause life threatening pneumonia.

"The JN.1 variant appears to have an increased affinity for lung tissue, potentially leading to more severe cases of pneumonia compared to earlier strains."

Testing is fairly useless as a person can be infectious 2-5 days before symptoms start and tests might only show as positive 2-5 days after symptoms appear:

In London the NHS is now reporting 2020 level emergency ambulance calls and major hospitals in the UK and USA are mandating.masks again for all employees.

@Stan at The Sorry DogGet a dog up ya
[img]https://gcdnb.pbrd.co/images/HmKgNRky9kMK.png
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Hay, Putin, I done hacked yer satalight 'n caused you goat-fornicators tar bomb yer own cuntry, little boy!!!

@Major DenmoreSo many false flags have been predicted lately, by both sides, that you could nuke New York and the Yanks would declare Civil War.

Ruski intelligence is predicting a Ukraine co-ordinated false flag in the form of a chemical attack to stir up further hatred against the Putin regime. The chemicals have already been procured by a US company from a supplier in Germany and an agent resembling old school mustard gas will be cooked up in one of the many Ukraine biowarfare labs. What a swell year 2024 is shaping up to be.

Question for Dr Knowitall
When a person is infected with HIV how long does it take for full blown AIDS to develop?

@Dr RobertAIDS is not an auto-immune disease. It is a viral infection that kills the CD4 T cells. So wrong there Doc.
As for the cited paper it does show some changes in T cells post COVID, particularly in old folks. But overall they ain't huge (unlike in AIDS in which the virus untreated can eliminate 99% of your CD4 T cells), and it would be good to follow up these people a bit longer than 2.5 months to see the changes. But they are there, and could have some downstream effects on the immune system. But it is not AIDS like, and exaggerating it is effect is not helping anyone.

"Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health" i.e. independent of Long Covid.

https://www.frontiersin.org/articles/10.3389/fimmu.2021.676932/full

Time to accept the facts. COVID-19 is an auto-immune disease along similar lines to AIDS (acquired immunodeficiency syndrome)

Happy New Year everybody.

Well, it's a new fucking year now and what can we expect? More of the same old fucking shit, over and over and over again. FFS where is Klaatu and Gort? We need the now more than ever!

Jackie Gleeson saw them back in the 50s: https://www.bitchute.com/video/WiHVlB8R4EMZ/
That's good enough for me. They are here, and have been here since the year dot!

@Hemlock HarryThey were a stopgap treatment. No more than that. Buying time until the ultimate vaccine could be made.
The ButtPlug 4000. This patented device will cram your arse with immune stimulating goodness. And you can do it all while you go about your normal day duties. Working, sleeping, eating, dreaming.
But please no anal sex.


Keep an eye on your mailbox, details will be arriving soon from your Government.

The wider scientific community now starting to rail against mRNA vaccines? Has science never been more all over the place before? It seems the world population would have been safer relying on homeopathy.

Les, I give you GUNS, now you run 'long 'n go git yer own damn FREEDOM!!! Jest not on Ricky's Plantation, ware its cabbage pick'n season soon.

Fuck the Heroes. Just give me freedom.
Sweet freedumb.

I found many of the Heroes of the 20th Century to be boisterous fools. With the love for living on the edge. Could be the edge of reality or edge of respectability, whatever it was they were there.
John Farnham and Kiwi PM Robert 'Piggy' Muldoon are two that spring to mind.

Seems like the Yank's litle adventure is over before it started. Piss weak

I was in the clink once. Not for as long as Assange. Well it wasn't really the clink. I actually got locked in a bathroom. I managed to unlock the door eventually. It felt quite isolating though. For a few hours. Well it was only a few minutes truth be told.

Maybe not. He has been in the clink so long. Surely they wouldn't do that to one of their own.

@RicardovitzHillbilly! Why are Yemani Houthi is a Man among men! He stands tall over his barren land a free man and no mans servant. He has disposed of many a white man trying to oppress him with the rules and whatnot of [I]European Civilization.[/I]
And they will be standing tall even when you have bent over and sold your foul smelling ass to the Atlanta proletariat.

Yemeni Houthi - Why we got them kind 'o swarthy, sand-aped in this hear World? They's rump-ugly. Done git rid 'o all thar Neandrathals a billion years ago. Killed 'em all of with thar bare hand!!! Strangled them nasty, filthy Neanderthals 'n curb-stomped thar thick skulls. Now, ain't this hear world a heap better off cuz MY kin folks git rid of Neandrathals??? Time tar git starded on them Yemeni Houthis. 'N then thar rest of them sand-apes 'n half-breed semi-tes shitt'n up 25% of the Earth's dirt.....er sand.

@PatriotIt seems that PM Albanese has turned his back on stalwart allies USA and Israel, and refused to help Operation Prosperity Guardian in protecting merchant ships in the Red Sea. What an absolute disgrace. Albo should know that backing down in the face of terrorism only emboldens those savages.
Meanwhile CCP dictator Xi quietly smiles as he has evidence in plain view of the weakness of the Australian Government. Expect some shenanigans from him in the northern Australian region soon.
God bless,
Patriot

That's Yakult isn't it? Can't fool me Dr Bob. The left over remains of Japan's biological warfare programme in WW2. Not only were the Japs making bugs like anthrax to kill us, they were also making 'superfoods' to keep their fanatical soldiers fighting.

And as such I wouldn't touch it with a barge pole. In fact I'd sooner eat my own shit then take their poison rubbish!

SIM01? I hear you ask.

"“Three bacterial strains, B adolescentis, Bifidobacterium bifidum and Bifidobacterium longum with three prebiotic compounds including galacto-oligosaccharides, xylo-oligosaccharides, and resistant dextrin"!

There may be some light at the end of the long dark covid tunnel. Make yourself a batch of SIM01!
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00685-0/fulltext

What's that dithering idiot Squeaky Albo gunna do? Bend over as usual or show some rare spine?

Georgie was a dern great presladent!!! Git rid 'o the assault weapon ban. Done gave Coinfederates thar guns back. Yessiree, I aim tar be like Georgie Busch II when I git tar be'n Prime Minister of Australia!!!

From this century, but a long time ago

Only those in the know, know the correct response to your question Patriot.
And I do and it is.

I think Mr ASPI has hit the nail on the head. How will the Chinese view it if Australia refuse their ally's call? They will rightfully view her as the weak link in the anti-authoritarian/democratic defense chain that protects the civilised world. So PM Albanese must respond immediately and send his ships to defend our sole democratic friend in the Middle East. For to do otherwise will allow that tyrant Xi and his genocidal regime to think that Australia is an easy picking, a land of cowards in fact. A land afraid of the fight for freedom and the right to do business unencumbered.

Well PM Albo, what are you? A Man or a Mouse?

God bless,
Patriot

Sure why not. Already selling those pricks parts for their planes to bomb the kids in Gaza. What's a boat between mass murdering friends.

@ChatoThere is no proof that Jesus was a good fella or even OK but according to one secular historian who spent half of her academic life studying the story of Jesus there are only two solid historical facts known about him that contradict your other assertions.
1. There was a man of his name baptised by a John The Baptist and 2. There was a man of his name crucified some years later. That is it. The rest is anecdotal or mythological.

@Dr RobertChrist, you are switched on Dr Robert. In my Ivory Tower we have also just received word of this paper, and I will be assessing it's relevance and accuracy shortly. But I wouldn't be jumping too far ahead; was already known COVID infects many cell types. The finding that it also infects CD4 T cells doesn't necessarily mean we are any closer or further to the COVID apocalypse that some crave.

@Dr KnowitallDr Knowitall should do some catching up before spreading mis-information and then putting his head in the sand.

Here is another important paper on the subject:

SARS-CoV-2 uses CD4 to infect T helper lymphocytes

"Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS- CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death."

https://elifesciences.org/articles/84790

Don't forget the Mafia!

@Denis (with one n)Fools! It is an umbrella of course.

As in there is a monster in your parsimony...
?si=X_BegG_X751je61I

@Looney LesI think it is a fish.

@Woozy in WollongongWhats that mate? Some German opera?

We are alone and our maladies are parsimony.

@Dr KnowitallDespite increasing evidence Covid related T cell depletion denialism is now a thing in the scientific community.

@Dr KnowitallOk checked out Dr Robert's (do people still pay money to see themself with you?) references. Many of thesm are commentary pieces rather than research. And very little direct evidence of permanent T cell depletion in COVID is presented. Which is completely different with HIV, where the virus targets the CD4 T cell and kills it.

But that doesn't mean COVID has no effect on immune system. It does, but to varying degrees for different people. And it is possible that there will be downstream debilitating effects on the immune system from it. But it is definitely not as much as in AIDS.

And with that no further correspondence will be entered into.

It's only long covid until you die.

Ok, long COVID different. Let me enlighten you later... Saving lives here!

T cell depletion was suspected early on in the pandemic. This first paper from 2019
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

COVID is a lympho-manipulative pathogen which creates a dysfunctional immune response:
https://www.frontiersin.org/articles/10.3389/fimmu.2020.600405/full

"Covid-19?s ability to interfere with how T cells recognize their viral particles is the reason why T cell responses fail and do not make the grade."
https://www.tandfonline.com/doi/full/10.1080/14760584.2022.20771960

"A research team that has autopsied people who died from COVID-19 has now discovered they lack so-called germinal centers, classrooms in the spleen and lymph nodes in which immune cells learn to mount a long-lasting antibody response to a pathogen."
https://www.science.org/content/article/coronavirus-may-shut-down-immune-system-s-vital-classrooms

Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773371/

A substantial proportion of patients who have recovered from coronavirus disease-2019 (COVID-19) experience COVID-19–related symptoms even months after hospital discharge. We extensively immunologically characterized patients who recovered from COVID-19. In these patients, T cells were exhausted, with increased PD-1+ T cells, as compared with healthy controls.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783674/

Persistence of SARS-CoV-2 and Long COVID - A spectrum of immune dysregulation
https://www.doherty.edu.au/news-events/setting-it-straight/issue-118-persistence-of-sarscov2-long-covid-spectrum-immune-dysregulation

We demonstrate that viral antigen-positive T cells from patient undergone pronounced apoptosis. In vitro infection of T cells induced cell death that is likely in mitochondria ROS-HIF-1a-dependent pathways.
https://www.nature.com/articles/s41392-022-00919-x

SARS COV-2 INFECTS T LYMPHOCYTES CAUSING THEIR EXHAUSTION AND APOPTOSIS CONTRIBUTING TO IMMUNE DYSFUNCTION AND LYMPHOPENIA THAT FAVORS VIRAL PERSISTENCE
https://www.researchgate.net/publication/359330070_SARS_COV-2_INFECTS_T_LYMPHOCYTES_CAUSING_THEIR_EXHAUSTION_AND_APOPTOSIS_CONTRIBUTING_TO_IMMUNE_DYSFUNCTION_AND_LYMPHOPENIA_THAT_FAVORS_VIRAL_PERSISTENCE

A recent study of 99 patients with long COVID found exhausted T cells that suggested the patients were fighting an active chronic infection. The strength of T-cell exhaustion also corresponded with the reactivation of Epstein-Barr virus in patients.
https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v1.full.pdf

Acquired lymphocytopenia can occur with a number of other disorders The most common causes include
Protein-energy undernutrition
HIV infection
COVID-19
https://www.msdmanuals.com/professional/hematology-and-oncology/leukopenias/lymphocytopenia

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19
https://www.pnas.org/doi/10.1073/pnas.2201541119

Microbiologist Brendan Crabb, director of Melbourne’s Burnet Institute told Bloomberg that he’d be surprised if COVID didn’t have an effect on the infectiousness of other diseases given its documented impairment of the immune system in long COVID patients. "You’ve got the best part of 100 million to half a billion people in the world who are very changed in their capacity to respond to viruses,” Crabb told Bloomberg. “There’s no way that can mean business as normal for microbial ecology.”
https://www.bloomberg.com/news/newsletters/2022-09-05/kids-with-liver-damage-polio-monkeypox-tomato-flu-viruses-are-behaving-badly


The risk of cardiovascular disease, for example, increased after one infection, but doubled in people who had two infections, and tripled in those who had been infected thrice. The numbers translate into 50 extra cases of heart disease per 1,000 people who've had COVID-19 twice
https://www.abc.net.au/news/health/2022-07-29/covid-19-three-myths-challenge-lies-ahead/101274980

Show us where is the evidence of depletion of T Cells after COVID? Havent seen any...

Depression is misanthropic denial.

Hyperactivation of T cells caused by COVID leads to their exhaustion and organ damage. With multiple exposures the depletion of T-Cells leads to weakened immune systems and premature death. It is an airborne auto-immune disease.

Hmmm... dont think it is like that. Where is evidence of actual decrease in immune cells like you see in AIDS? Haven't seen any.
But that doesnt mean COVID is a 'harmless' cold. It is a serious disease that does have some ill effects for some people. And that can include immune system issues. The problem with COVID is that it now entrenched with us, and even if only a small % get bad effects, the fact that people will have multiple reinfections means the number of us getting these bad effects will be large.

SARS-CoV-2 is like airborne HIV. And like HIV approx 10 years before it presents as full blown AIDS

@BrianNo way. The Yanks are gunna fold on the Ukies? Who will ever trust them again...

@Sergent SchultzFT: "The White House has issued a blunt warning that the US is set to run out of funds to aid Ukraine by the end of the year"